| T2S1040 |
Jolkinolide B
|
|
ERK
,
IL Receptor
,
BCL
,
p38 MAPK
,
TNF
,
NF-κB
,
Akt
,
Caspase
,
PI3K
,
JAK
,
JNK
,
STAT
,
mTOR
|
|
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can be used for studies on preventing and treating osteolysis. |
| T4S1173 |
Agrimol B
|
|
Sirtuin
,
PPAR
|
|
1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb. |
| T13475 |
β-Aminopropionitrile
|
3-Aminopropionitrile,BAPN |
Others
,
Endogenous Metabolite
|
|
β-Aminopropionitrile (3-Aminopropionitrile) is a selective inhibitor of lysyl oxidase. |
| T3417 |
Amentoflavone
|
Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin |
Apoptosis
,
P450
,
Phospholipase
,
Reactive Oxygen Species
,
Opioid Receptor
,
COX
,
Antibacterial
,
RSV
,
Antifungal
|
|
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib... |
| T1048 |
Estradiol
|
E2,17β-Estradiol,17β-Oestradiol,β-Estradiol |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
,
Endogenous Metabolite
|
|
Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor be... |
| T2851 |
Daphnetin
|
7,8-Dihydroxycoumarin,Daphnetol |
EGFR
,
PKA
,
PKC
,
Parasite
,
Autophagy
|
|
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-... |
| TN1818 |
Kaempferol 3-O-β-D-glucuronide
|
Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,Kaempferol-3-glucuronide |
IL Receptor
|
|
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide)e has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal α²-glucuronidase from various human cells. |
| T2882 |
Genistin
|
Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside |
Apoptosis
,
Estrogen Receptor/ERR
,
Others
|
|
Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities |
| TN6924 |
Anhydrosafflor yellow B
|
(2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,AHSYB |
Others
|
|
Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,... |
| T3404 |
Cucurbitacin B
|
Cuc B,DATISCACIN,Amarine |
Apoptosis
,
PTEN
,
Integrin
,
Endogenous Metabolite
,
HIF
,
STAT
,
Autophagy
|
|
Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inh... |
| T6S1843 |
Tenacissoside I
|
Tenacissimoside B |
Others
|
|
Tenacissoside I (Tenacissimoside B),Tenacissosides B, C and marsdenoside K inhibit the proliferation of Raji, NB4 and K562 cells in vitro significantly, in a dose and time dependent manner. |
| TN1880 |
Lucidenic acid B
|
Lucidenicacid B |
Apoptosis
,
Caspase
|
|
Lucidenic acid B (Lucidenicacid B), a natural compound extracted from Ganoderma lucidum, induces activation of caspase-9 and caspase-3 and cleavage of PARP, which can induce apoptosis in human leukemia cells through mito... |
| T3S1265 |
Liriopesides B
|
Nolinospiroside F |
Others
|
|
Liriopesides B (Nolinospiroside F) exhibited potential anticancer activity against human ovarian cancer A2780 cells. |
| TN2359 |
Iristectorigenin B
|
Iristectrigenin B |
Liver X Receptor
|
|
Iristectorigenin B (Iristectrigenin B) is a potent hepatic X-receptor (LXR) modulator, a small molecule compound isolated from Belamcanda chinensis.Iristectrigenin B promotes the expression of ABCA264 and ABCG7 in macrop... |
| T6S0735 |
Flavokawain B
|
Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone |
Apoptosis
,
Others
|
|
1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, in... |
| TN6771 |
Malabaricone B
|
|
Others
|
|
Malabaricone B is a Spice-derived phenolic, it induces mitochondrial damage in lung cancer cells via a p53-independent pathway. |
| T5780 |
HYPOCRELLIN B
|
|
Apoptosis
,
Parasite
,
Antifungal
|
|
HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer cells, and inhibits proliferation of Staphylococcus by incre... |
| T4S1796 |
Heterophyllin B
|
|
PI3K
|
|
Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associa... |
| T1022 |
Hygromycin B
|
Hygrovetine |
ribosome
,
Antibacterial
,
Antibiotic
,
Antifungal
|
|
Hygromycin B (Hygrovetine) is an aminoglycoside antibiotic that inhibits protein synthesis by interfering with translocation and causing mistranslation of the 70S ribosome. Hygromycin B can be used to screen prokaryotic ... |
| TQ0309 |
Glaucocalyxin B
|
|
Autophagy
|
|
|
| T3519 |
Formosanin C
|
Polyphyllin B |
Apoptosis
,
Caspase
|
|
Formosanin C (Polyphyllin B) is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal systems. |
| T8852 |
Tubuloside B
|
|
Apoptosis
,
Others
|
|
The neuroprotective effect of tubuloside B, one of the phenylethanoids isolated from the stems of Cistanche salsa, on tumor necrosis factor-alpha (TNFalpha)-induced apoptosis in SH-SY5Y neuronal cells. |
| TN2256 |
Taccalonolide B
|
|
Microtubule Associated
|
|
Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM. |
| TN7236 |
Cephalandole B
|
|
IL Receptor
|
|
cephalandole B, an indole alkaloid isolated from cyanide, significantly inhibited IL-17A gene expression and suppressed IL-17A luciferase reporter in Jukat cells in a dose-dependent manner. |
| T3771 |
Methyl protodioscin
|
Smilax saponin B,NSC-698790 |
Apoptosis
|
|
Methyl protodioscin (Smilax saponin B) potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl protodioscin induced apoptotic process in h... |
| TN1620 |
Eriocalyxin B
|
|
Apoptosis
,
cAMP
,
NF-κB
,
STAT
|
|
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inh... |
| TN2100 |
Pratensein
|
|
Others
,
NF-κB
|
|
Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells. |
| T2S1120 |
Ganoderenic acid B
|
|
P-gp
|
|
Ganoderenic acid B, a natural product derived from Ganoderma lucidum, can work by inhibiting the transport function of ABCB1 and enhancing the cytotoxicity of chemotherapy drugs against AbCB1-mediated multidrug resistant... |
| T3976 |
Cytosporone B
|
Csn-B,Dothiorelone G |
Others
|
|
Cytosporone B (Dothiorelone G) is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM). Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene... |
| T2S1975 |
Ponicidin
|
Rubescensine B |
Apoptosis
,
JAK
,
STAT
|
|
Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens. Ponicidin exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicidin induces apoptosis of gastric carcinoma ... |
| TN6909 |
Polyporusterone B
|
(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one |
Others
|
|
Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) is a triterpene carboxylic aci... |
| TN2211 |
Silybin B
|
Silibinin B |
Apoptosis
,
Beta Amyloid
,
Bcr-Abl
|
|
Silybin B (Silibinin B) is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with free radical scavenging activity of 1, 1-dipheny... |
| T4A2399 |
Cinobufotalin
|
|
IL Receptor
,
Akt
,
MRP
,
P-gp
|
|
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent... |
| TN3209 |
3′,4′,7-Trihydroxyflavone
|
|
ATPase
,
Others
,
p38 MAPK
,
NF-κB
|
|
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclasto... |
| T1507 |
Streptozocin
|
STZ,Streptozotocin,NSC-85998,U 9889 |
DNA Alkylator/Crosslinker
,
DNA Alkylation
,
DNA/RNA Synthesis
,
Antibacterial
,
Antibiotic
,
Autophagy
|
|
Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. Th... |
| T3717 |
Hinokitiol
|
4-Isopropyltropolone,β-thujaplicin |
DNA Methyltransferase
,
Virus Protease
,
Estrogen/progestogen Receptor
,
Nrf2
|
|
Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent... |
| T3S2325 |
Ardisiacrispin A
|
Saxifragifolin B,LTS-4,Deglucocyclamin |
HSV
|
|
Ardisiacrispin A (Deglucocyclamin) has cytotoxic activity toward HepG2 cancer cell with the GI(50) value of 1.56μM, it could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule... |
| T1660 |
Silibinin
|
Silibinin A,Silybin,Silymarin I |
Reactive Oxygen Species
,
Autophagy
|
|
Silibinin (Silybin) is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin an... |
| T5S0527 |
Rhodojaponin III
|
|
Others
|
|
1. Rhodojaponin III has antifeedant and oviposition deterrence effects against many kinds of insects, BdorCSP2 of B. dorsalis could be involved in chemoreception of Rhodojaponin III and played a critical role. 2. Rhodoja... |
| T4717 |
25-Hydroxycholesterol
|
|
Others
,
Endogenous Metabolite
,
HMG-CoA Reductase
|
|
25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regu... |
| T3S1955 |
7-Ethylcamptothecin
|
|
Others
|
|
1. 7-Ethylcamptothecin has the superior antitumor activity than CPT. (a). 7-Ethylcamptothecin has a stronger growth-inhibiting activity against tumor cells. (b). 7-Ethylcamptothecin remains in the intestinal tract for a ... |
| T5680 |
Aloin(mixture of A&B)
|
|
MMP
,
IL Receptor
,
Antibacterial
,
Antifungal
|
|
ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells. |
| T36473 |
Trans-Nerolidol
|
|
|
|
trans-Nerolidol is a sesquiterpene that has been found in various plants, includingC. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.1,2,3,4In... |
| T7028 |
Licochalcone C
|
LICOCHALCONEC |
Phosphatase
,
Antioxidant
,
Glucosidase
|
|
Licochalcone C (LICOCHALCONEC) has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, and anti-apoptotic activit... |
| T2787 |
Picroside I
|
6'-Cinnamoylcatalpol |
MMP
,
STAT
|
|
Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may be the valuable anti-invasive drug ... |
| TWS1977 |
Kamebakaurin
|
Kamebakaurine |
NF-κB
|
|
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression... |
| T1257 |
Bestatin
|
Ubenimex |
Others
,
Aminopeptidase
,
Antibacterial
,
Antibiotic
,
LTR
|
|
Bestatin (Ubenimex) competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Amin... |
| T6429 |
Caffeic Acid Phenethyl Ester
|
Phenylethyl Caffeate,CAPE |
Apoptosis
,
NF-κB
|
|
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective... |
| T3S2344 |
β,β-Dimethylacrylshikonin
|
Dimethylacrylshikonin,β, β-Dimethylacrylshikonin |
ERK
,
HIF/HIF Prolyl-Hydroxylase
|
|
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant... |
| T0798 |
Triamcinolone
|
Fluoxyprednisolone,Aristocort,Rodinolone |
Glucocorticoid Receptor
,
COX
|
|
Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to transloca... |
